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目的:探讨Nn 2O(笑气)滥用所致脑血流量(CBF)的改变。n 方法:回顾性分析2017年12月至2018年10月间于中日友好医院就诊的24例笑气滥用患者[男9例，女15例，年龄18~32(24.0±8.9)岁]脑血流灌注显像图，计算各脑区(基底节、脑中央区、小脑、扣带回、额叶、内侧颞叶、枕叶、顶叶、颞叶)与后台软件数据库的同年龄段正常人相应感兴趣区(ROI)摄取的差异统计值。差异统计值>1.68为局部脑血流灌注升高；<-1.68为局部脑血流灌注减低。各脑区左、右双侧差异统计值的相关性采用Pearson相关分析，差异统计值与临床各指标相关性采用Spearman相关分析。结果:各脑区左、右两侧差异统计值均有相关性(n r值：0.503~0.892，均n P<0.05)。额叶、颞叶CBF降低比例较高，分别为62.5%(15/24)及70.8%(17/24)；扣带回CBF增加比例较高(33.3%, 8/24)。额叶(n rs＝0.375)、脑中央区(n rs＝0.305)与笑气滥用时长有相关性(均n P1.68 indicated the increase of local CBF perfusion, while statistic < -1.68 indicated the decrease of local CBF perfusion. The correlation between the statistics of bilateral brain regions and the correlation between statistical values and clinical indicators were analyzed by Pearson and Spearman correlation analyses.Results:The correlation of the statistics between bilateral regions of each brain area was significant(n r values: 0.503-0.892, all n P<0.05). The decreased CBF proportions of frontal and temporal lobes were 62.5%(15/24) and 70.8%(17/24), respectively. The highest proportion of increased CBF was cingulate gyrus (33.3%, 8/24). There were significant correlations between frontal lobe, central brain area and duration of laughing gas abuse (n rs values: 0.375, 0.305, both n P<0.05).n Conclusion:CBF perfusion imaging is helpful for understanding the changes of CBF in patients with laughing gas abuse.