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目的观察表观健康人群血糖、血脂和血清蛋白含量随年龄变化的趋势,为参考范围的建立和疾病预防提供科学依据。方法募集表观健康体检志愿者4041名,收集年龄和性别信息,使用全自动生化分析仪检测血糖(GLU)、血脂(TC、HDLc、LDLc、TG)、血清总蛋白(TP)和白蛋白(ALB),分析这些指标随年龄的变化趋势。结果血糖、血脂和血清蛋白随年龄呈递增或递减的单向变化趋势(P<0.01)。GLU(5.05±0.43)mmol/L、TC(4.39±0.6)mmol/L、LDLc(2.39±0.51)mmol/L和TG(0.79±0.34)mmol/L血清含量随年龄递增,HDLc(1.52±0.3)mmol/L、TP(74.03±3.81)g/L和ALB(47.79±2.86)g/L随年龄递减,Cox-Stuart.趋势检验发现这种随年龄单调变化趋势具有统计学意义(P<0.01)。结论血糖、血脂和血清蛋白在表观健康人群中具有增龄现象,提示临床建立参考范围时应考虑年龄因素的影响。对糖尿病、冠心病和其他老年性慢性疾病应监测血糖、血脂和血清蛋白的改变,以便进行早防早诊早治。
Objective To observe the trend of blood glucose, blood lipid and serum protein in the healthy population with age, and provide a scientific basis for the establishment of reference range and disease prevention. Methods A total of 4041 volunteers were enrolled in this study. The age and sex information were collected and the levels of blood glucose (GLU), blood lipids (TC, HDLc, LDLc, TG), serum total protein (TP) and albumin ALB), analysis of these indicators with the trend of age. Results The blood glucose, blood lipid and serum protein showed a one-way trend of increasing or decreasing with age (P <0.01). Serum levels of GLU (5.05 ± 0.43) mmol / L, TC (4.39 ± 0.6) mmol / L, LDLc (2.39 ± 0.51) mmol / L and TG (0.79 ± 0.34) mmol / L increased with age, HDLc ), mmol / L, TP (74.03 ± 3.81) g / L and ALB (47.79 ± 2.86) g / L decreased with age. Cox-Stuart trend test showed that the trend of monotonous changes was statistically significant ). Conclusion Blood glucose, serum lipids and serum albumin have an increasing age in apparently healthy people, suggesting that age-related factors should be considered in establishing the reference range. For diabetes, coronary heart disease and other senile chronic diseases, blood glucose, blood lipids and serum proteins should be monitored for early prevention and early diagnosis.