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为了研究自由基在动脉粥样硬化过程中的作用,建立了家兔动脉粥样硬化模型。实验组随着TC,LDL-C的升高,LPO由0.30上升到2.12△D_(233)/ml,是对照组的14倍。TC,LDL-C与LPO呈明显正相关(r=0.69,r=0.67,P<0.05)。但是,随着LPO的上升,GSH-Px逐渐下降,是对照组的0.57,0.35倍。SOD在两组间差异无显著性(P>0.05)。结果表明,检测LPO和GSH-Px对由于动脉粥样硬化引起的心脑血管病的诊断、疗效评估和预后有重要意义。
In order to study the role of free radicals in atherosclerosis, a rabbit model of atherosclerosis was established. With the increase of TC and LDL-C in the experimental group, the LPO increased from 0.30 to 2.12 △D_(233)/ml, 14 times that of the control group. There was a significant positive correlation between TC, LDL-C and LPO (r=0.69, r=0.67, P<0.05). However, as the LPO rose, GSH-Px gradually decreased, which was 0.57, 0.35 times that of the control group. There was no significant difference in SOD between the two groups (P>0.05). The results showed that the detection of LPO and GSH-Px is of great significance for the diagnosis, therapeutic evaluation and prognosis of cardiovascular and cerebrovascular diseases caused by atherosclerosis.