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目的探讨盐酸多奈哌齐对创伤性脑损伤(TBI)后认知功能障碍的干预作用及其对TBI临床预后的影响。方法将TBI后合并认知障碍患者86例,随机分成治疗组和对照组,治疗组应用盐酸多奈哌齐10mg,每日一次服用;对照组应用吡拉西坦0.8g,每日三次服用。两组的治疗周期为12周。治疗前及治疗后,分别应用简明精神状态检测量表(MMSE)、国人修订成人韦氏智利量表(WAIS-RC)和格拉斯哥预后评分(GOS)来评价疗效。结果治疗后12周两组MMSE和WAIS-RC评分均较治疗前提高(P<0.05)。治疗后12周,治疗组MMSE和WAIS-RC评分较对照组高(P<0.05),治疗组预后优良率优于对照组(P<0.05)。结论盐酸多奈哌齐对TBI后认知障碍有积极治疗作用,并能改善其预后。
Objective To investigate the intervention effect of donepezil hydrochloride on cognitive dysfunction after traumatic brain injury (TBI) and its influence on the clinical prognosis of TBI. Methods Eighty-six patients with cognitive impairment after TBI were randomly divided into treatment group and control group. The treatment group was treated with donepezil hydrochloride 10 mg once daily while the control group was treated with piracetam 0.8 g three times daily. The two groups were treated for 12 weeks. Before treatment and after treatment, the patients were assessed by MMSE, WAIS-RC and GOS. Results The scores of MMSE and WAIS-RC in both groups were significantly increased 12 weeks after treatment (P <0.05). After 12 weeks of treatment, MMSE and WAIS-RC scores of the treatment group were higher than those of the control group (P <0.05). The excellent and good rate of the treatment group was better than that of the control group (P <0.05). Conclusion Donepezil hydrochloride has a positive therapeutic effect on post-TBI cognitive impairment and can improve its prognosis.