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为了研究每日24小时周期节律和饮食中蛋白摄入对庆大霉素药代动力学的影响。10名受检查者晚8时进餐后禁食至次日晨8时,静注庆大霉素1.5mg/kg。同一组受检者隔二周后,于晨8时进餐后禁食至次日晨8时,静注庆大霉素1.5mg/kg。同一组受检者隔二周后,于晨8时进餐后禁食至晚8时,静注同样剂量的庆大霉素。还是同一组受检者中的6名,再隔二周后于晚5时进餐,给予蛋白90克,1.5小时后再给予同样剂量的庆大霉素。三次试验皆在注射庆大霉素后6个小时内的不同时间间隔,取样检查其血清及尿中的含量。
In order to study the effects of daily 24-hour cycle rhythm and dietary protein intake on gentamicin pharmacokinetics. 10 subjects were inspected at 8:00 pm after fasting to 8:00 the next morning, intravenous injection of gentamicin 1.5mg / kg. Subjects in the same group were fasted for two weeks at two o’clock in the morning and fasted at 8:00 am and then injected with gentamicin 1.5 mg / kg intravenously at 8 am the following morning. Subjects in the same group were fasted with the same dose of gentamicin twice a week after fasting at 8 am and up to 8 pm. Six of the subjects in the same group also drank at 5 p.m. after two weeks, giving 90 g of the protein and the same dose of gentamycin 1.5 hours later. The three tests were performed at different time intervals within 6 hours after injection of gentamicin, and the contents of serum and urine were sampled for sampling.