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AIM:To evaluate the effects of prucalopride on intestinalprokinetic activity in fast rats and to provide experimentalbasis for clinical treatment of gastrointestinal motility diseases.METHODS:Gastrointestinal propulsion rate was measuredby the migration rate of activated charcoal,which reflexesgastrointestinal motility function.120 Spraque-Dawley rats wererandomly divided into four groups and received an intravenousinjection of physiological saline (served as control),prucalopride1 mg/kg,prucalopride 2 mg/kg and cisapride 1 mg/kg,respectively.The gastrointestinal propulsion rate was measured1,2 or 4 hours after intravenous injection of the drugs.RESULTS:Significant accelerations of gastrointestinalpropulsion rate in prucalopride 1 mg/kg and 2 mg/kg groupswere found compared with control group at 2 and 4 hours(83.2 %±5.5 %,81.7 %±8.5 % vs70.5 %±9.2 %,P<0.01;91.2 %±2.2 %,91.3 %±3.9 % vs86.8 %±2.6 %,P<0.01).The gastrointestinal propulsion rates at 1,2 or 4 hours werefaster in prucalopride 1 mg/kg and 2 mg/kg groups thanin cisapride group (84.0 %±11.7 %,77.1%±11.9 % vs66.3 %±13.6 %,P<0.01,P<0.05;83.2 %±5.5 %,81.7 %±8.5 % vs75.4 %±5.9 %,P<0.01,P<0.05;91.2 %±2.2 %,91.3 %±3.9 % vs 88.6 %±3.5 %,P<0.05,P<0.05).Nodifference of gastrointestinal propulsion rate was foundbetween prucalopride 1 mg/kg group and prucalopride2 mg/kg group (P>0.05).CONCLUSION:Prucalopride accelerates intestinal motilityin fast rats,and has no dose dependent effect.
AIM: To evaluate the effects of prucalopride on intestinal prokinetic activity in fast rats and to provide experimental basis for clinical treatment of gastrointestinal motility diseases. METHODS: Gastrointestinal propulsion rate was measured by the migration rate of activated charcoal, which reflexes gastrointestinal motility function. 120 Spraque-Dawley rats wererandomly divided into four groups and received an intravenous injection of physiological saline (served as control), prucalopride 1 mg / kg, prucalopride 2 mg / kg and cisapride 1 mg / kg, respectively.The gastrointestinal propulsion rate was measured for 1, 2 or 4 hours after intravenous injection of the drugs .RESULTS: Significant accelerations of gastrointestinalpropulsion rate in prucalopride 1 mg / kg and 2 mg / kg groupswere found compared with control group at 2 and 4 hours (83.2% ± 5.5%, 81.7% ± 8.5% vs 70.5% ± 9.2%, P <0.01; 91.2% ± 2.2%, 91.3% ± 3.9% vs 86.8% ± 2.6%, P <0.01) .The gastrointestinal propulsion rates at 1,2 or 4 hours were found in prucal opride 1 mg / kg and 2 mg / kg groups than in cisapride group (84.0% ± 11.7%, 77.1% ± 11.9% vs 66.3% ± 13.6%, P <0.01, P <0.05; 83.2% ± 5.5%, 81.7% ± 8.5% vs 75.4% ± 5.9%, P <0.01, P <0.05; 91.2% ± 2.2%, 91.3% ± 3.9% vs 88.6% ± 3.5%, P <0.05, P < rate was found between prucalopride 1 mg / kg group and prucalopride 2 mg / kg group (P> 0.05) .CONCLUSION: Prucalopride accelerates intestinal motility in fast rats, and has no dose dependent effect.