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目的了解脂质蓄积指数(LAP)与缺血性心血管病(ICVD)发病风险的关系。方法 2011年9月-2012年6月随机抽取成都市社区居民为调查对象,对其进行问卷调查,并行血生物化学指标、血压、腰围、踝臂脉搏波传导速度(Ba PWV)、反射波增强指数等检查。Pearson相关分析用于探讨LAP与心血管危险因素水平、Ba PWV、反射波增强指数的关系。线性回归法用于分析LAP与ICVD发病风险的关系。结果共有780例资料齐全的调查对象纳入分析。LAP与血压、总胆固醇水平、空腹血糖水平等传统心血管危险因素呈正相关(P<0.05),与Ba PWV也呈正相关(P<0.05)。LAP与ICVD发病风险呈正相关(r=0.253,P<0.001),但对性别、年龄、吸烟状况等多种心血管危险因素进行校正后这种相关关系减弱(r=0.050,P<0.001)。结论 LAP升高会伴随较高的心血管危险因素水平和亚临床血管损伤,可在一定程度上预测中国人群ICVD的发生。但由于相关性微弱,不推荐将该指标直接用于临床。LAP与ICVD的关系尚需基于不同年龄段、不同种族的大样本前瞻性队列研究证实。
Objective To understand the relationship between the lipid accumulation index (LAP) and the risk of ischemic cardiovascular disease (ICVD). Methods From September 2011 to June 2012, community residents in Chengdu were randomly selected as the survey subjects. Questionnaires were conducted and the blood biochemical parameters, blood pressure, waist circumference, ankle brachial pulse wave velocity (Ba PWV) and reflex wave were increased Index and other checks. Pearson correlation analysis was used to investigate the relationship between LAP and cardiovascular risk factors, Ba PWV and reflex enhancement index. Linear regression was used to analyze the relationship between the incidence of LAP and ICVD. Results A total of 780 cases with complete data were included in the analysis. LAP was positively correlated with traditional cardiovascular risk factors such as blood pressure, total cholesterol and fasting blood glucose (P <0.05), and positively correlated with Ba PWV (P <0.05). There was a positive correlation between the incidence of LAP and ICVD (r = 0.253, P <0.001). However, the correlation was weaker (r = 0.050, P <0.001) after adjusting for various cardiovascular risk factors such as gender, age and smoking status. Conclusions LAP elevation will be associated with higher cardiovascular risk factors and subclinical vascular injury, which may to a certain extent predict the occurrence of ICVD in Chinese population. However, due to the weak correlation, it is not recommended to use this indicator directly in clinical practice. The relationship between LAP and ICVD needs to be confirmed by a large cohort of prospective cohorts of different age groups and ethnicities.