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业已证实,生理系统最低重力暴露的需求存在较大差异。例如,在血管与骨这两个截然不同系统之间的初步比较研究得知,两者不仅在组织水平的力学调控机制差异较大,且失重性骨质丢失还与钙沉积-吸收的变化有关。间断性人工重力对血管的有效防护作用可能与血管拥有在1 G重力环境下恢复其原有预应力和张力整合状态的“记忆”功能有关。除长期的钙沉积-吸收过程,骨组织还涉及成骨细胞和破骨细胞更为复杂的张力整合模型机制。细胞水平的钙动力学模型(Cell ML)业已提出,我们希望生理组学能够利用这类模型框架进一步解释骨组织对间断性人工重力反应性低下的机制;并评估“间断性”或“连续性”人工重力方案何者更适用于未来探索级航天飞行任务。
It has been demonstrated that there is a large difference in the needs for the lowest gravity exposure of physiological systems. For example, a preliminary comparative study between two distinct systems, vascular and bone, revealed that there is not only a large difference in the mechanistic regulatory mechanisms between the two, but also the loss of bone loss associated with changes in calcium deposition-absorption . The potent protective effect of intermittent artificial gravity on blood vessels may be related to the “memory” function of blood vessels that have their original prestress and tension conformability restored at 1 G gravity. In addition to long-term calcium deposition-absorption processes, bone tissue is also involved in a more complex model of tension-integrating models of osteoblasts and osteoclasts. The cell-level calcium kinetics model (Cell ML) has suggested that we hope that physiology groups can use this model framework to further explain the mechanism by which bone tissue is responsible for intermittent artificial gravity remissions; and to evaluate “intermittent” or “ The ”continuity" artificial gravity scheme is more suitable for future exploration-level space missions.