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尿毒症周围神经病是慢性肾功能衰竭时较为常见的神经并发症,其特点是周围神经的运动及感觉纤维同时受累。临床表现为四肢末端的感觉异常,如针刺、麻木、烧灼感等,尤以夜间更为明显。由于感觉异常,特别是下肢不适,致使患者难以保持安静。随着病程进展,患者逐渐发生感觉丧失,四肢无力,走路不稳,最后,四肢末端可发生肌肉萎缩,肌力减退,甚至瘫痪。组织学表明主要是轴索远端的脱髓鞘病变,系继发于轴索变性所致。近10年来,随着分析化学和电生理技术的发展,对尿毒症周围神经病有了比较详细的研究,现就有
Uremia Peripheral neuropathy is a more common neurologic complication of chronic renal failure characterized by the simultaneous involvement of motor and sensory fibers in the peripheral nerves. Clinical manifestations of extremities feel abnormal, such as acupuncture, numbness, burning sensation, especially at night is more obvious. Due to abnormal sensation, especially lower extremity discomfort, it is difficult for the patient to keep quiet. As the course of the disease progresses, patients experience loss of sensation gradually, weakness in the limbs, unsteady walking, and finally, muscle atrophy, muscle weakness, and even paralysis can occur at the extremities. Histology showed that the main distal axonal demyelinating lesions, Department of secondary to axial degeneration caused. In the past 10 years, with the development of analytical chemistry and electrophysiological techniques, there has been a more detailed study of uremic peripheral neuropathy.