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采用免疫组织化学技术检测了22例晚期血吸虫病（下称晚血）患者肝内T细胞亚群，发现T细胞集中分布于虫卵肉芽肿外层，在非肉芽肿部位散在分布于虫卵附近，而广泛纤维化的区域内无T细胞浸润。肉芽辟和非内芽肿部位的T细胞均以CD8+细胞为主。19例患者脾脏内T细胞观察，发现脾脏动脉周围淋巴鞘和边缘区的CD4+细胞百分比和CD4+／CD8+比值显著降低，CD8+T细胞百分比明显提高，而且由于脾脏纤维化，导致红素区T细胞稀疏，动脉周围淋巴鞘T细胞外移，本文讨论了以上结果在晚血免疫调控中的作用。
Immunohistochemical technique was used to detect intrahepatic T cell subsets in 22 patients with advanced schistosomiasis (hereinafter referred to as late blood). T cells were found to be concentrated on the outer layer of the egg granuloma and scattered around the non-granuloma site , While there is no T cell infiltration in the extensive fibrosis area. Granulation and non-endodermal granuloma T cells are CD8 + cells. T lymphocytes from 19 patients showed that the percentage of CD4 + cells and the ratio of CD4 + / CD8 + in lymphoid sheath and marginal zone of splenic artery were significantly decreased and the percentage of CD8 + T cells was significantly increased. Due to the splenic fibrosis, T lymphocytes Sparse, periarterial lymphoid T cell migration, this article discusses the above results in the role of late immune regulation.