【摘 要】
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BACKGROUND AND OBJECTIVEMedications to improve cognitive impairment among patients with Alzheimer′s Disease include acetylcholinesterase inhibitors and N-Methyl-D aspartame receptor antagonists. Howev
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BACKGROUND AND OBJECTIVEMedications to improve cognitive impairment among patients with Alzheimer′s Disease include acetylcholinesterase inhibitors and N-Methyl-D aspartame receptor antagonists. However, these drugs often have only limited and transient effects. As recent studies have suggested that repetitive transcranial magnetic stimulation (rTMS) may be effective for improving cognition in older adults, this systematic review and meta-analysis was designed to clarify the efficacy of this treatment modality for patients with mild cognitive impairment.
METHODSAfter completing an extensive medical literature search, the authors identified 13 published studies of which 9 were randomized controlled trials. From these, 7 parallel-group randomized controlled trials with complete outcome data were used for the final analysis. Most of the subjects had mild to moderate cognitive impairment at the onset of the trials.
RESULTSSubjects included elderly patients with cognitive impairment, with 107 in the active and 87 in the sham treatment. The most common target of the rTMS was the dorsolateral prefrontal cortex. With sessions ranging from 1-30 per study treatment, and most including five sessions per week, those treated with rTMS were found to have a moderate improvement in cognition (P＝0.01). No serious side effects were reported in the studies.
CONCLUSIONThis study found that high frequency repetitive transcranial magnetic stimulation may improve cognition among elderly patients with mild to moderate cognitive impairment.
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