【摘 要】
：
Compared to conventional hyperthermia that is limited by low selectivity and severe side effects,nano-enabled hyperthermia yields great potentials to tackle these limitations for cancer treatment.Another major advance is the observation of immunological r
【机 构】
：
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,National Center for Nanosc
论文部分内容阅读
Compared to conventional hyperthermia that is limited by low selectivity and severe side effects,nano-enabled hyperthermia yields great potentials to tackle these limitations for cancer treatment.Another major advance is the observation of immunological responses associated with nano-enabled hyperthermia,which introduces a new avenue,allowing a potential paradigm shift from the acutely effective and cytotoxicity-centric response to the next-phase discovery,i.e.,long-lasting and/or systemic anti-tumor immunity.This perspective first discusses the temperature-gradient and the spatially-structured immuno-logical landscape in solid tumors receiving nano-enabled hyperthermia.This includes the discussion about under-lying mechanism such as immunogenic cell death,which initiates a profound immunological chain reaction.In order to propagate the immune activation as a viable therapeutic principle,we further discussed the tumor type-specific complexity in the immunological tumor microenviron-ment,including the creative design of nano-enabled combination therapy to synergize with nano-enabled hyperthermia.
其他文献
The tumor microenvironment features over-expressed hydrogen peroxide (H2O2).Thus,versatile therapeutic strategies based on H2O2 as a reaction substrate to generate hydroxyl radical (·OH) have been used as a prospective therapeutic method to boost anticanc
Composite materials have elicited much inter-est because of their superior performance in the removal of toxic and radioactive uranyl ions from aqueous solutions.With polyethyleneimine as a functional group,carboxy-lated chitosan as a matrix,and oxidizing
Chemical industry is always seeking opportu-nities to efficiently and economically convert raw materials to commodity chemicals and higher value-added chemical-based products.The life cycles of chemical products involve the procedures of conceptual produc
Alkylation of benzene to value-added,high octane number and low toxic toluene and xylenes provides a way to lower benzene content in gasoline pool,and is hence a method to promote fuel quality.On the other hand,CO2 accumulation in the atmosphere causes gl
Production cost,capacitance,and electrode materials safety are the key factors to be concerned about for supercapacitors.In this work,a type of carbon nanosheets was produced through the carbonization of tripotassium citrate monohydrate and nitric acidifi
Advanced model-based control strategies,e.g.,model predictive control,can offer superior control of key process variables for multiple-input multiple-output sys-tems.The quality of the system model is critical to controller performance and should adequate
To study the dynamic behavior of a process,time-resolved data are collected at different time instants during each of a series of experiments,which are usually designed with the design of experiments or the design of dynamic experiments methodologies.For
The catalytic hydrogenation of carboxylic acid to alcohols is one of the important strategies for the conversion of biomass.Herein,a series of Ni-doped PtSn catalysts were prepared,characterized and studied in the hydrogenation of acetic acid.The Ni dopan
Solvent-based post-combustion capture tech-nologies have great potential for CO2 mitigation in traditional coal-fired power plants.Modelling and simula-tion provide a low-cost opportunity to evaluate perfor-mances and guide flexible operation.Composed by
Simulation is besides experimentation the major method for designing,analyzing and optimizing chemical processes.The ability of simulations to reflect real process behavior strongly depends on model quality.Validation and adaption of process models are us