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目的:探讨糖尿病并发突发性聋全身和局部激素治疗的效果和并发症发生差异。方法:按照患者知情并同意原则将76例患者分为全身激素治疗(全身用药组)和局部激素治疗(局部用药组)两组,各组均为38例(39耳),两组除激素应用方法不同外,其他治疗方法一致。治疗2周后评估两组患者听力、耳鸣、眩晕治愈效果和主要并发症发生率,治疗1个月后评估两组患者并发症发生情况。结果:全身用药组和局部用药组听力、耳鸣、眩晕治愈效果相似,差异无统计学意义(P>0.05),局部用药组并发症发生率明显高于全身用药组(P<0.05),治疗1个月后全身用药组并发症完全消失,局部用药组仍有2例中耳感染和1例鼓膜穿孔存在。结论:糖尿病并发突发性聋患者全身激素治疗与局部激素治疗效果相当,但全身激素治疗具有使用方便、费用较低、并发症少且易控制等优势,故糖尿病并发突发性聋患者只要血糖能及时有效控制,仍然以全身激素治疗为好。
Objective: To investigate the effect and complications of systemic and local hormonal therapy in patients with diabetes complicated by sudden deafness. Methods: According to the principle of informed consent of patients, 76 patients were divided into two groups: systemic hormone therapy (systemic therapy group) and local hormone therapy (topical therapy group), 38 cases (39 ears) in each group. Different methods, other treatment methods are the same. After 2 weeks of treatment, the hearing, tinnitus, vertigo curative effect and the incidence of major complication were evaluated in both groups. Complications were evaluated after 1 month of treatment in both groups. Results: The curative effect of hearing, tinnitus and vertigo were similar between the systemic drug group and the topical drug group, with no significant difference (P> 0.05). The incidence of complications in the local drug group was significantly higher than that in the systemic drug group (P <0.05) After a month, the complications of systemic administration disappeared completely. There were still 2 cases of middle ear infection and 1 case of tympanic membrane perforation in the local drug group. Conclusion: Systemic hormonal therapy in patients with diabetes mellitus and sudden deafness is similar to that of local hormone therapy. However, systemic hormone therapy has the advantages of convenient use, lower cost, fewer complications and easy to control. Therefore, patients with diabetes mellitus complicated with sudden deafness should only have blood glucose Can be timely and effective control, still with systemic hormones as well.