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目的:探讨孕妇的下肢深部形成静脉血栓后炎症因子的变化以及对患者的影响。方法:选取2007年3月～2011年8月孕妇40例,将40例孕妇按是否患有DVT分为A、B两组,A组为正常孕妇组,B组为患有DVT的孕妇组,每组20例,观察两组孕妇的炎症因子变化。结果:患有下肢深部静脉血栓的孕妇的TNF-α、IL-6、IL-10、hs-CRP、INF-γ水平明显高于正常组孕妇。通过对20例不同程度DVT患者血栓病情的形成、稳定、恢复、再复发四个病程中炎症因子的测定得出,随着炎症因子水平不断增高,血栓越严重,炎症因子水平越高。结论:患有DVT孕妇的炎症因子数明显高于正常组孕妇,且炎症因子的水平和患者的患病程度成正比。其临床意义为在下肢深部形成静脉血栓的过程中有炎症因子的参与,影响患者的生理病理过程并增加了孕妇的DVT患病率。
Objective: To investigate the changes of inflammatory factors and the influence on the patients after the formation of venous thrombosis in pregnant women. Methods: Forty pregnant women from March 2007 to August 2011 were enrolled. 40 pregnant women were divided into two groups according to whether they had DVT or not. Group A was normal pregnant women, while group B was pregnant women with DVT. Group of 20 cases, observed two groups of pregnant women changes in inflammatory cytokines. Results: The levels of TNF-α, IL-6, IL-10, hs-CRP and INF-γ in pregnant women with deep venous thrombosis of lower limbs were significantly higher than those in normal pregnant women. Through the determination of inflammatory factors in four stages of thrombosis, stable, recovery and recurrence of thrombosis in 20 patients with different degrees of DVT, it was found that with the increase of inflammatory cytokines, the more severe the thrombus, the higher the level of inflammatory cytokines. Conclusion: The number of inflammatory cytokines in pregnant women with DVT is significantly higher than that of normal pregnant women, and the level of inflammatory cytokines is proportional to the degree of disease in the patients. Its clinical significance for the formation of venous thrombosis in the deep lower limbs in the process of inflammatory factors involved, affecting the patient’s physiological and pathological processes and increased the prevalence of pregnant women with DVT.