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Objective:To investigate the antidiarrheal activity of the methanol leaf extract of Pterocarpus erinaceus in vivo.Methods:The methanol leaf extract of Ptemcarpus erinaceus was evaluated using different doses(100,200 and 400 mg/kg body weight) orally for antidiarrheal activity using castor oil-induced diarrhea,charcoal meal transit lime and castor oil-induced enteropooling in different groups of albino Wistar mice.The activity of the extract at different doses were compared to diphenoxylate(3 mg/kg) and atropine sulphate(3 mg/kg) which were used as standard reference drugs and also to the distilled water administered negative control group of mice.Results:The extract at the doses used caused a significant(P< 0.01) reduction in the wet faeces passed by the mice in the castor oil-induced diarrhea,decreased the distance travelled by the charcoal meal by up to 54.8%and also caused a dose dependent and significant(P< 0.001) reduction in the intraluminal fluid accumulation in the castor oil-induced enteropooling. Conclusions:Our results indicate that Pterocarpits erinaceus extract produced significant antidiarrheal activity and the action may attribute to inhibition of gastrointestinal movement and fluid secretion.
Objective: To investigate the antidiarrheal activity of the methanol leaf extract of Pterocarpus erinaceus in vivo. Methods: The methanol leaf extract of Ptemcarpus erinaceus was evaluated using different doses (100,200 and 400 mg / kg body weight) orally for antidiarrheal activity using castor oil- induced diarrhea, charcoal meal transit lime and castor oil-induced enteropooling in different groups of albino Wistar mice. The activity of the extract at different doses were compared to diphenoxylate (3 mg / kg) and atropine sulphate (3 mg / kg) which were used as standard reference drugs and also to the distilled water administered negative control group of mice. Results: The extract at the doses used caused a significant (P <0.01) reduction in the wet faeces passed by the mice in the castor oil-induced diarrhea , decreased the distance travel by the charcoal meal by up to 54.8% and also caused a dose dependent and significant (P <0.001) reduction in the intraluminal fluid accumulation in the castor oil-i nduced enteropooling. Conclusions: Our results indicate that Pterocarpits erinaceus extract has significant antidiarrheal activity and the action may attribute to inhibition of gastrointestinal movement and fluid secretion.