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锌是一种广泛存在并被认为是人体所必需的微量元素。已知有70多种金属酶的作用要有锌参与。虽然与其它必需微量元素比较锌的毒性要小得多,但仍有报道酸性食物或饮料腐蚀镀锌器皿引起的中毒。也有静脉注射过量锌而引起急性致死性锌中毒的报道,以及职业性接触中的“金属烟热(Metal fume fever)”。作者测定了16种络合剂缓解急性醋酸锌中毒的相对效果。选用雄性Swiss种小鼠,体重25±2g。16种络合剂:乙二胺四乙酸二钠钙(Na_2CaEDTA)、L-半胱氨酸、N-乙酰基-L-半胱氨酸(NAC)、水杨酸钠、谷胱甘肽、二乙撑三胺五乙酸三钠钙(Na_3CaDTPA)、乙撑双四乙酸二钠钙(Na_2CaEGTA)、1,2-环乙撑二氮川四乙酸二钠钙(Na_2CaCDTA)、2,3-二巯基-1-丙烷磺酸(DMPS)、2,3-二巯基琥珀
Zinc is a ubiquitous trace element found to be essential to the body. More than 70 types of metallo-enzymes are known to have zinc involved. Although toxicity of zinc is much smaller compared with other essential trace elements, there is still a report of poisoning caused by the corrosion of galvanized utensils by acidic food or drink. There are also reports of acute lethal zinc poisoning caused by intravenous injection of excess zinc, as well as “Metal fume fever” in occupational exposure. The authors determined the relative effect of 16 complexing agents on acute zinc acetate poisoning. Male Swiss mice were selected and weighed 25 ± 2g. Sixteen complexing agents: calcium disodium edetate, L-cysteine, NAC-L-cysteine (NAC), sodium salicylate, glutathione, (Na_3CaDTPA), calcium distearate (Na_2CaEGTA), calcium disodium 1,2-cyclohexanediacetate (Na_2CaCDTA), 2,3-bis Mercapto-1-propanesulfonic acid (DMPS), 2,3-dimercaptosuccinate