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目的探讨尿碱性成纤维细胞生长因子(bFGF)用于鉴别血管瘤和血管畸形、判断血管瘤是处于增生期或消退期以及动态监测血管瘤病程的作用。方法对133例患儿(包括增生期血管瘤69例、消退期血管瘤41例及血管畸形23例),应用酶联免疫吸附试验,检测尿bFGF浓度,并以无上述血管病变的唇腭裂11例患儿作为对照。结果增生期血管瘤患儿尿bFGF浓度显著高于消退期血管瘤、血管畸形患儿和对照患儿。前3者与对照患儿比较,差异均有统计学意义(P<0.01);后3者之间两两比较,差别均无统计学意义(P>0.05)。结论尿bFGF浓度有助于鉴别血管瘤和血管畸形;并可判断血管瘤是处于增生或消退期及动态监测血管瘤病程,可为分析血管瘤的发生机制提供依据。
Objective To investigate the role of basic fibroblast growth factor (bFGF) in the identification of hemangiomas and vascular malformations and to determine whether hemangiomas are in the proliferative or exacerbation stages and to dynamically monitor the course of the hemangiomas. Methods 133 cases of children (including 69 cases of proliferative hemangioma, 41 cases of regression hemangioma and 23 cases of vascular malformations), urinary bFGF concentration was detected by enzyme-linked immunosorbent assay, and without the above-mentioned vascular lesions of cleft lip and palate 11 Cases of children as a control. Results The urinary bFGF concentration in proliferative hemangiomas was significantly higher than that in patients with hemangiomas, vascular malformations and controls. The difference between the former three groups and the control group was statistically significant (P <0.01). There was no significant difference between the latter three groups (P> 0.05). Conclusions Urinary bFGF concentration can help to distinguish hemangiomas and vascular malformations. It can also be used to judge the course of hemangiomas in hyperplasia or remission and to monitor the course of hemangiomas dynamically, which may provide the basis for the analysis of the pathogenesis of hemangiomas.