Glycogen synthase kinase-3β positively regulates the proliferation of human ovarian cancer cells

• 作 者: Qi Cao Xin Lu You-Ji Feng
• 机 构: DepartmentofGynecology
• 出 处: 细胞研究：英文版
• 发表日期: 2006年7期
• 关键词: 糖原合酶激酶-3Β 酶活性 卵巢肿瘤 肿瘤细胞 glycogen synthase kinase 3β ovarian cancer cell prolif
• 基金项目: AcknowledgmentsWe thank Dr Y Rao （Northwestem University） for generously providing Axin GID5-6/pCS2MT, Axin GID5- 6LP/pCS2MT and GSK-313 S9A/pCS2 plasmids and YC Jia, CX Huang, Y Hou for critical disc

<正> Although glycogen synthase kinase-3(GSK-3)might act as a tumor suppressor since its inhibition is expected tomimic the activation of Wnt-signaling pathway,GSK-3β may contribute to NF-κ3 activation in cancer cells leading toincreased cancer cell