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肝细胞癌(hepatocellular carcinoma,HCC)的地理分布和以移民患者多见,提示该病是由某种或多种环境因素引起。现已发现,慢性乙型肝炎病毒(hepatitis B Virus,HBV)感染、霉菌毒素特别是黄曲霉素污染食物和肝硬化可能是人类HCC的3大常见病因。HCC常伴发肝硬化,但两者的确切关系尚未明了。肝细胞癌与肝硬化具有密切关系的证据两者的密切关系表现在两方面: 肝硬化病人发生HCC的危险增高很久以来已发现部分肝硬化病人在临床上发生HCC,或在尸解时诊断出HCC。两者的并发率主要决定于肝硬化的类型(或分期)和
The geographical distribution of hepatocellular carcinoma (HCC) is more common in migrant patients, suggesting that the disease is caused by one or more environmental factors. It has been found that chronic hepatitis B virus (HBV) infection, mycotoxins, especially aflatoxins, and cirrhosis may be the three most common causes of HCC in humans. HCC often accompanied by cirrhosis, but the exact relationship between the two is not yet clear. Evidence of a close relationship between hepatocellular carcinoma and cirrhosis is manifested in two aspects: Increased risk of developing HCC in patients with cirrhosis A long history of HCC in patients with cirrhosis has been found in clinical practice or at the time of autopsy HCC. The incidence of both depends mainly on the type of cirrhosis (or staging) and