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局部产生的前列腺素,主要是PGE_2和前列环素(PGI_2),对胃粘膜具有细胞保护作用,预先应用PGE_2或PGI_2可预防阿斯匹林造成的大鼠胃溃疡.PGE_2对人消化性溃疡的治疗效果已得到实验证实,但PGI_2对人胃粘膜的细胞保护作用尚未见报告.本文应用随机双盲法进行研究,观察外源性PGI_2对人胃溃疡愈合的影响.方法:选30名患者,胃镜证实为单个溃疡(直径2～3cm,边缘厚度1cm),症状持续不超过1年,无其它夹杂疾患.随机分为两组;15人每日接受PGI_2静脉注射(5ng/kg/min×5h),连续6天;另15人接受安慰剂.所有患者在接受注射前一天、注射疗程结束后第2天和第8天分别做胃镜检查,观察溃疡愈合情况,
Locally produced prostaglandins, mainly PGE 2 and prostacyclin (PGI 2), have a cytoprotective effect on gastric mucosa, and pretreatment with PGE 2 or PGI 2 can prevent gastric ulcer in rats induced by aspirin.PGE 2 has a protective effect on human gastric ulcer The effect of PGI_2 on human gastric mucosa has not been reported yet.In this paper, a randomized double-blind study was conducted to observe the effect of exogenous PGI_2 on the healing of gastric ulcer.Methods: Thirty patients, Gastroscopy confirmed as a single ulcer (diameter 2 ~ 3cm, edge thickness 1cm), the symptoms persisted for no more than 1 year, no other inclusions disorders were randomly divided into two groups; 15 were daily intravenous PGI_2 (5ng / kg / min × 5h ) For 6 consecutive days.The other 15 patients received placebo.All patients underwent gastroscopy on the day before injection and on the 2nd and the 8th day after the injection treatment to observe the ulcer healing,