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目的 :评价奥美拉唑对肝源性溃疡 (HU)的疗效。方法 :对 2 5 1例肝硬化经胃镜检查出溃疡的 48例患者 ,予每日晨服奥美拉唑 2 0mg ,疗程 4～ 6周 ,着重观察胃镜下溃疡愈合情况 ,并与同期消化性溃疡 (PU)疗效对比分析。结果 :4周愈合率HU组中 ,十二指肠溃疡 (DU)为 69.2 % (18/ 2 6例 ) ,胃溃疡 (GU)为 5 2 .9% (9/ 17) ;PU组中DU与GU为 10 0 % (3 1/ 3 1与 6/ 6例 ) ,两组比较差异有非常显著性 (P <0 .0 1)。 6周愈合率HU中DU为 84.6% (2 2 / 2 6) ,GU为 82 .3 % (14 / 17例 )。肝功能ChildC级者溃疡愈合率明显降低。结论 :奥美拉唑治疗HU疗效满意 ,但疗程较PU长 ,尤其肝功能CHildC级者
Objective: To evaluate the curative effect of omeprazole on liver ulcer (HU). Methods: Forty-eight patients with gastric ulcer diagnosed by liver cirrhosis were enrolled in daily morning service omeprazole 20 mg for 4 to 6 weeks. The ulcer healing under endoscopy was observed, The comparative analysis of curative effect of ulcer (PU). Results: In the HU group, the duodenal ulcer (DU) was 69.2% (18 of 26 cases) and the gastric ulcer (GU) of the HU group was 5.29% (9/17) And GU was 100% (31/31 and 6/6), the difference between the two groups was significant (P <0.01). At 6 weeks, DU was 84.6% (2 2/26) in DU and 82.3% (GU / 14 cases) in GU. Liver function ChildC grade ulcer healing rate was significantly reduced. Conclusion: Omeprazole is effective in treating HU, but its duration is longer than that of PU, especially CHildC