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编者按肝脏是人体重要的代谢器官、能量供给及免疫调节的场所之一,大多数药物需在肝脏内进行氧化、还原、水解等化学反应,在药物的生物转化和清除中起主导作用,易受药物诱发而导致损害.药物本身很少引起肝脏损害,但经肝脏药物代谢酶的生物转化而形成的药物代谢产物通常是引起肝脏结构及功能损害的更直接原因.药物性肝病是临床常见的药物不良反应之一,急性肝损伤是药物性肝病最常见的发病形式,少数可发生威胁生命的肝衰竭.急性药物性肝病病程一般在3 mo内(胆汁淤积型病程较长,
Editor’s note: The liver is one of the most important metabolic organs, energy supply and immunoregulatory sites in the body. Most drugs require chemical reactions such as oxidation, reduction and hydrolysis in the liver to play a leading role in the bioconversion and elimination of drugs. Drug-induced damage caused by the drug itself rarely cause liver damage, but the drug metabolism by the hepatic drug metabolism of drug metabolites formed by the liver structure and function is usually caused more directly damage the cause of drug-induced liver disease is clinically common One of the adverse drug reactions, acute liver injury is the most common form of drug-induced liver disease, a small number can occur in life-threatening liver failure.Acute drug-induced liver disease generally within 3 mo (cholestatic longer duration,