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1970～1977年间,日本仙台国立医院外科接受输血的1,082名病人中,116例发生非甲非乙型肝炎,占10.7%。根据临床资料这些肝炎可分为两类:1型:SGPT急剧升降,呈单峰;平均潜伏期5.7周,平均转氨酶升高时间5.8周。此型又可称为短潜伏、短病程型。2型:SGPT升高呈双峰,第一个峰急升骤降,并继之以第二个高峰,此后则为逐渐下降;平均潜伏期7.2周,转氨酶升高时间17.5周。此型又可称为长潜伏期、长病程型。本组病例中,1型为52例,2型30例。此外,尚有第3型34例,SGPT升高为一平段;潜伏期7.4周,转氨酶升高时间15.3周,因此与2型类似。应用双向免疫扩散法,对非甲非乙型输血后肝炎病人的急性期和恢复期血清相互测试,证明13例2型病人的急性期血清中均存在一种新的抗原,称为丙型
Between 1970 and 1977, out of 1,082 patients who underwent surgical transfusion surgery at Sendai National Hospital in Japan, 116 developed non-A, non-B hepatitis, accounting for 10.7%. According to clinical data of these hepatitis can be divided into two categories: type 1: SGPT steep rise and fall, showing a single peak; the average incubation period of 5.7 weeks, the average rise of transaminase in 5.8 weeks. This type can be called short latent, short course of disease. Type 2: SGPT increased bimodal, the first peak plummeted, followed by the second peak, and then gradually decreased; the average latency of 7.2 weeks, 17.5 weeks elevated transaminase. This type can be called a long incubation period, long course of disease type. In this group of patients, type 1 was 52 cases, type 2 30 cases. In addition, there are 34 cases of type 3, SGPT increased to a flat section; incubation period of 7.4 weeks, elevated aminotransferases 15.3 weeks, and therefore similar to the type 2. Application of two-way immunodiffusion method, non-A non-hepatitis B patients with acute and convalescent sera tested each other to prove that 13 cases of type 2 patients with acute phase of serum are present in a new antigen, known as type C