【摘 要】
：
Recent studies have revealed that the property of drug is mainly associated with the body\'s substance and energy metabolism.The present study aimed to evaluate the drug property of Poria,called Fuling (FL) in traditional Chinese medicine (TCM),in terms
【机 构】
：
College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China
论文部分内容阅读
Recent studies have revealed that the property of drug is mainly associated with the body\'s substance and energy metabolism.The present study aimed to evaluate the drug property of Poria,called Fuling (FL) in traditional Chinese medicine (TCM),in terms of its effects on the substance and energy metabolism in rat models of cold-deficiency and heat-deficiency syndromes,compared with Aconiti Lateralis Radix Praeparaia,called Fuzi (FZ) in TCM,with hot property,and Anemarrhenae Rhizoma,called Zhimu (ZM) in TCM,with cold property,as reference drugs,respectively.The appearance score,toe and rectal temperatures of the animals treated were assessed at different time points.Several indices in vivo correlated with substance and energy metabolism (glucokinas,phosphoglycerate kinase,cytochrome c reductase,cytochrome c oxydase,and Na+-K+-ATPase),endocrine system (triiodothyronine,thyroxine,and 17-hydroxycorticosteroid),nervous system (acetylcholin esterase),and cyclic nucleotide system were determined.The changes in appearance score and indices in vivo suggested the successful establishment of cold-deficiency and heat-deficiency syndrome models.FZ reversed the decreased levels of indices (substance and energy metabolism and endocrine system) and alleviated the syndrome of cold-deficiency model,and ZM showed obviously therapeutic effect on heat-deficiency syndrome (appearance score,substance and energy metabolism,and endocrine system).FL could alleviate cold-deficiency syndrome and raise the decreased levels of glucokinas,phosphoglycerate kinase,cytochrome c reductase and tfiiodothyronine in cold-deficiency model,but had no significant effect on heat-deficiency syndrome.Drug property of FL was inferred as trending to “flat and warm ”,which still need further study.It was advisable to adopt both cold-deficiency and heat-deficiency models to study the drugs with “flat” property.
其他文献
Four new triterpene saponins, mandshunosides F-I (1-4), together with five known compounds (5-9), were isolated from the roots and rhizomes of Clematis mandshurica.Their structures were elucidated on the basis of spectroscopic evidences and hydrolysis pro
In the present study,28 Chinese medicinal herbs belonging to traditional Chinese medicine (TCM) for the treatment of type 2 diabetes were selected to explore the application of network pharmacology in developing new Chinese herbal medicine formulae for th
Novel series of limonin derivatives (V-A-1-V-A-8,V-B-1-V-B-8) were synthesized by adding various tertiary amines onto the C (7)-position of limonin.The synthesized compounds possessed favorable physicochemical property,and the intrinsic solubility of the
A series of new hybrids of dehydroandrographolide (TAD),a biologically active natural product,bearing nitric oxide (NO)-releasing moieties were synthesized and designated as NO-donor dehydroandrographolide.The biological activities of target compounds wer
Buyang Huanwu Decoction (BYHWD) is a well-known traditional Chinese medicine prescription which is used to treat ischaemic stroke and stroke-induced disabilities.However,the exact mechanism underlying BYHWD\'s amelioration of ischaemic stroke and its ef
Sesquiterpene lactones are considered as the major active compounds in Kudiezi injection in virtue of their special structures and activities.Herein, an analytical method was developed for rapid screening and identification of sesquiterpene lactones in Ku
Nine new ent-kaurane diterpenoids,named scopariusols L-T (1-9),were isolated from the aerial parts of Isodon scoparius.Their structures were characterized mainly by analyzing the NMR and HR-ESI-MS data,and the absolute configuration of 1 was determined by
Two new furan fragment isomerized limonoids,meliazedalides A and B (compounds 1 and 2),were isolated from the fruits of Melia azedarach Lirm..Their chemical structures were elucidated on the basis of HR-ESI-MS and 1D and 2D NMR data,which belonged to nimb