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本文从药效动力学角度,选择对小鼠自发活动抑制作用为效应观测指标,探讨了镇肝熄风扬与天麻钩藤饮两方的体内过程,并求得各方程及相应参数,结果表明:两方的起效剂量较低,作用期及半衰期亦较短。提示两方在用于临床镇静治疗时,似可降低给药量,并缩短给药间隔时间。
From the point of pharmacodynamics, this article selects the inhibitory effect on spontaneous activity of mice as an effect observation index, and discusses the in vivo processes of Zhenfang Xifeng Yang and Tianma Gouteng Drink, and obtains each equation and corresponding parameters. The results show that : The two parties have lower effective doses, shorter duration of action and shorter half-life. It is suggested that when used in clinical sedation, the two parties may reduce the dose and shorten the interval between dosing.