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本文研究了小鼠在宽的剂量范用内（１０，２０，４０，８０，１００，１２０，１４０，１６０，１８０，２００ｍｇ／ｋｇｂｗ）口服锌（Ｚｎ）盐时，对肝金属硫蛋白（ＭＴ）合成的影响。结果显示：因服用过量Ｚｎ（２＋），按剂量──效应关系发生肝ＭＴ的诱导合成，而且在肝Ｚｎ浓度和肝ＭＴ浓度之间存在正向关系。表明Ｚｎ是一个ＭＴ的诱导剂。在口服Ｚｎ８０～１００ｍｇ／ｋｇ的剂量范围时，无论是肝ＭＴ水平或肝Ｚｎ水平均有明显的改变。提示：在Ｚｎ诱导ＭＴ合成中，存在一个敏感的剂量范围。
In this paper, we investigated the effect of MT on the expression of hepatic metallothionein (MT) when oral zinc (Zn) was orally administered to mice at a wide dose range (10, 20, 40, 80, 100, 120, 140, 160, 180, 200 mg / ) Synthesis. The results showed that, due to the excessive administration of Zn (2+), the induction of liver MT synthesis occurred in a dose-effect relationship, and there was a positive relationship between the concentration of liver Zn and the concentration of liver MT. Zn is an MT inducer. In the oral Zn80 ~ 100mg / kg dose range, both liver MT level or liver Zn levels were significantly changed. Tip: In Zn-induced MT synthesis, there is a sensitive dose range.