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Brookline Ave nue, Boston, MA 02215, United States] Background: The association of light to moderate alcohol consumption with ris k for ischemic stroke remains controversial, as do the roles of beverage type an d drinking pattern. Objective: To assess the association of drinking patterns an d beverage type with risk for ischemic stroke among men. Design: Prospective coh ort study. Setting: United States. Participants: 38156 male health professionals who were free of known cardiovascular disease or cancer at baseline in 1986. Me asurements: With a semi quantitative food frequency questionnaire, the autho rs individually ascertained consumption of regular and light beer, red and white wine, and liquor every 4 years. Alcohol consumption was categorized as light (0 .1 to 9.9 g/d, or < 1 drink daily), moderate (10.0 to 29.9 g/d, or 1 to 2 drinks daily), and heavier (≥ 30.0 g/d, or ≥ 3 drinks daily). Results: During a foll ow up period of 14 years, 412 cases of incident ischemic stroke were documente d. Compared with abstainers, light drinkers had a multivariate adjusted relati ve risk of 0.99 (95% CI, 0.72 to 1.37), moderate drinkers had a multivariate adjusted relative risk of 1.26 (CI, 0.90 to 1.76), and heavier drinkers had a m ultivariate adjusted relative risk of 1.42 (CI, 0.97 to 2.09; P =0.01 for tren d). Consumption of 10.0 to 29.9 g of alcohol per day on 3 to 4 days per week app eared to be associated with the lowest risk (relative risk, 0.68 [CI, 0.44 to 1. 05]). Red wine consumption was inversely associated with risk in a graded manner (P = 0.02 for trend), but other beverages were not. The apparently higher risk for ischemic stroke with heavier alcohol use appeared to be most pronounced for the embolic subtype. Limitations: This study had limited power to examine specif ic drinking patterns and heavy drinking and could not assess risk for hemorrhagi c stroke. Conclusions: In this sample of male health professionals, light and mo derate average alcohol use was generally not associated with an increased risk f or ischemic stroke, although drinking pattern and beverage type modified this re lation. Intake of more than 2 drinks per day may be associated with a higher ris k for ischemic stroke.
Brookline Ave nue, Boston, MA 02215, United States] Background: The association of light to moderate alcohol consumption with ris k for ischemic stroke remains controversial, as do the roles of beverage type an drinking pattern. Objective: To assess the association of Drinking patterns an d beverage type with risk for ischemic stroke among men. Design: Prospective cohort study. Setting: United States. Participants: 38156 male health professionals who were free cardiovascular disease or cancer at baseline in 1986. Me asurements: With a semi-quantitative foodfrequency questionnaire, the autho rs individually ascertained consumption of regular and light beer, red and white wine, and liquor every 4 years. Alcohol consumption was categorized as light (0 .1 to 9.9 g / d, or < 1 drink daily), moderate (10.0 to 29.9 g / d, or 1 to 2 drinks daily), and heavier (≥ 30.0 g / d, or ≥ 3 drinks daily). Results: During a foll ow-up period of 14 years , 412 cases of incident ischemic Compared with abstainers, light drinkers had a multivariate adjusted adjusted of risk of 0.99 (95% CI, 0.72 to 1.37), moderate drinkers had a multivariate adjusted relative risk of 1.26 (CI, 0.90 to 1.76), and heavier drinkers had am ultivariate-adjusted relative risk of 1.42 (CI, 0.97 to 2.09; P = 0.01 for tren d). Consumption of 10.0 to 29.9 g of alcohol per day on 3 to 4 days per week app eared to be associated with the lowest risk (relative risk, 0.68 [CI, 0.44 to 1.05]). Red wine consumption was inversely associated with risk in a graded manner (P = 0.02 for trend), but other beverages were not. The apparently higher risk for ischemic stroke with heavier alcohol use 制 to to the most pronounced for the embolic subtype. Limitations: This study had limited power to examine specif ic drinking patterns and heavy drinking and could not assess risk for hemorrhagi c stroke. Conclusions: In this sample of male health professionals, light and mo derate a verage alcohol use was generally not associated with an increased risk f or ischemic stroke, although drinking pattern and beverage type modified this re lation. Intake of more than 2 drinks per day may be associated with a higher ris k for ischemic stroke.