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细胞信号转导异常同人类疾病的关联是目前生命科学研究的热点之一,对揭示疾病发生的本质具有极其重要的作用。一些病毒的致病机制即源于其抗原所致宿主细胞内信号转导的紊乱,病毒抗原通过蛋白质-蛋白质间相互作用而调控细胞内信号分子的生物活性。丙型肝炎病毒是丙型肝炎的致病因子,其感染的明显特征为引起严重肝脏疾病及易于慢性迁延且无满意的治疗药物。迄今关于丙型肝炎发病机制和病毒持续存在的分子基础仍不清楚。病毒蛋白通过干扰宿主细胞内信号转导级联反应而致异常信号转导很可能为其致病机制,故丙型肝炎病毒各种蛋白对宿主细胞信号转导影响的研究将有助于从一全新角度深入了解其致病机制,从而提出病毒致病的新模式。
The association of cell signal transduction abnormalities with human diseases is one of the hot spots in life science research, which plays an extremely important role in revealing the nature of the disease. The pathogenic mechanism of some viruses stems from the disturbance of signal transduction in host cells caused by their antigens. The viral antigens regulate the biological activity of intracellular signaling molecules through protein-protein interactions. Hepatitis C virus is a causative agent of hepatitis C, and the obvious feature of the infection is the non-satisfactory therapeutic drug that causes severe liver disease and is prone to chronic prolongation. So far the molecular basis for the pathogenesis of hepatitis C and the persistence of viruses remains unclear. Virus protein by interfering with signal transduction cascade host cells caused by abnormal signal transduction pathway is likely to be its pathogenic mechanism, so a variety of hepatitis C virus protein host cell signal transduction studies will help from a A new perspective on understanding its pathogenic mechanism, which proposed a new model of the virus pathogenic.