Hypothermic intervention for 3 hours inhibits apoptosis in neonatal rats with hypoxic-ischemic brain

• 作 者: Yale Guo Zhankui Li Ruilin Li
• 机 构: DepartmentofPediatrics,DepartmentofNeonatology,DepartmentofPathology
• 出 处: 中国神经再生研究：英文版
• 发表日期: 2011年22期
• 关键词: 缺血性脑损伤 大鼠模型 细胞凋亡 新生儿 小时 缺氧 大脑皮层 末端标记 hypothermia hypoxia ischemia neural protect

A neonatal rat model of hypoxic-ischemic brain damage was designed and implemented in this study. Rats were subjected to hypothermia at 31°C immediately following hypoxia-ischemia for either 3, 6 or 15 hours. TdT-mediated dUTP nick end labeling demon