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目的 探索广东省新生儿听力筛查的临床方法,了解广东省新生儿听力损失的发病状况,以便制定适合广东省新生儿听力筛查的实施方案,提出听力损失的婴幼儿的早期干预措施。方法 应用畸变产物诱发耳声发射技术(简称DPOAE)对27322例出生后2～4天的新生儿进行听力筛查(初筛),未通过者于生后6周复筛,对复筛未通过者,于生后3个月左右采用多频稳态听觉诱发反应(ASSR)测听技术进行听力学诊断。对有听损失高危因素者于6个月～3岁之间每半年监测一次听力变化。结果 自2001年7月至2003年11月,四家医院可供听力筛查的新生儿数为33706例,实际接受初筛查27322例,新生儿初筛率为81.05%;初筛通过23332例(85.45%),需复筛的共3990例,实际复筛人数 3391例,通过3003例,门诊复筛率为84%。复筛未通过例数388例,复筛后阳性率为1.4%。确诊新生儿先天性听力损失28例。由本组资料显示新生儿先天性听力损失在筛查儿中的发病率为1.02‰(单耳和双耳)。单耳听力损失在筛查儿中的发病率为0.29‰,双耳听力损失在筛查儿中的发病率为0.73‰。初筛的阳性率为 14.55%。假阳性率为14.51%,两步筛查后的阳性率为1.40%,假阳性率为1.33%。本组未发现假阴性病例。结论 通过应用畸变产物诱发耳声发射技术(DPOAE)、ASSR对新生儿进行听力筛查以及听力学诊
Objective To explore the clinical methods of neonatal hearing screening in Guangdong Province to understand the incidence of neonatal hearing loss in Guangdong Province in order to make a suitable implementation plan for neonatal hearing screening in Guangdong Province and to provide early interventions for infants and young children with hearing loss. Methods A total of 27,322 neonates aged 2 ~ 4 days after birth were subjected to hearing screening (initial screening) with distorted product evoked otoacoustic emission technique (DPOAE), while those who failed the screening were screened 6 weeks after birth, He was diagnosed with audiometry using multi-frequency steady-state auditory induction (ASSR) audiometry at about 3 months after birth. For those who are at risk of hearing loss, hearing changes are monitored every six months between 6 months and 3 years of age. Results From July 2001 to November 2003, the number of newborns available for hearing screening in the four hospitals was 33,706. The number of newborns actually receiving initial screening was 27,322 and the rate of newborn screening was 81.05% (85.45%), a total of 3990 cases need to be re-screened, the number of the actual rescreening 3391 cases, through 3003 cases, outpatient re-screening rate was 84%. 388 cases failed to pass the re-screening, the positive rate after re-screening was 1.4%. Diagnosis of neonatal congenital hearing loss in 28 cases. According to this group of data, the incidence of neonatal congenital hearing loss in screening children was 1.02 ‰ (monaural and binaural). The incidence of single-ear hearing loss in screening children was 0.29 ‰, and the hearing loss in both ears was 0.73 ‰ in screening children. The positive rate of primary screening was 14.55%. The false positive rate was 14.51%. The positive rate after two-step screening was 1.40% and the false positive rate was 1.33%. This group did not find false negative cases. CONCLUSIONS: Distortion-induced otoacoustic emission (DPOAE), ASSR hearing screening and audiology