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当今,制药工业的飞速发展,大批新药,特别是止痛药、麻醉药、新型农药和加工剂型的问世、发展与广泛应用,加之管理不善,控制不严,使中毒案件有逐年增多之势.法庭科学要求毒物工作者提供快速、准确的毒物及其代谢物的鉴定方法.常用的TLC、UV、HPLC、IR、GC等分析方法,固然有许多优点,但就应用范围,检测灵敏度和对未知物结构定性、定量分析均不如MS法.GC/MS仪作为复杂有机混合物快速、灵敏、可靠的鉴定技术在法庭科学鉴定中已获得越来越广泛的应用.早在70年代初,美国法医毒物学家首先将它用于毒物分析.经过二十几年的发展,已形成有机质谱应用的重要分支——法庭科学质谱.这期间,高效毛细管色/质(HRGC/MS)技术、电离技术、离子传输技
Today, the rapid development of the pharmaceutical industry, the advent of a large number of new drugs, especially painkillers, narcotics, new pesticides and processed dosage forms, development and extensive application, coupled with poor management and lax control, have increased the number of poisoned cases year by year. Science requires toxicologists to provide rapid and accurate identification of poisons and their metabolites. Commonly used analytical methods such as TLC, UV, HPLC, IR, GC, etc., have many advantages, but in terms of application scope, detection sensitivity and sensitivity to unknowns Structure qualitative and quantitative analysis are not as good as the MS method.GC / MS instrument as a complex organic mixture of fast, sensitive and reliable identification techniques in forensic science has been more widely used.As early as the early 1970s, the United States Forensic Toxicology At first, it was used in toxicological analysis. After more than two decades of development, it has formed a forensic science mass spectrometer, an important branch of organic mass spectrometry. During this period, high-performance capillary color / mass spectrometry (HRGC / MS), ionization, Transmission technology