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在人补体系统30多种成分中,约有一半左右的分子中含有某种共有的结构序列。目前已悉,这些基序有SCR(CCP)、TSR、EGF前体、LDL-R、FIM、SP区等。在补体分子中,有的只含有一种基序,如RCA分子只含有SCR,P分子中只含有TSR;有的含有多种基序,如C6、C7、C8及C9等。某种基序在补体分子中所占比重有多、有少,如H因子及C4bp几乎全由SCR组成,P分子大部由TSR组成;有的仅占分子结构的一部分,如C2、Bf、MCP、DAF、C9等。上述基序在分子中的位置,有的在氨基端,有的在羧基端。有的两端都有。本文介绍了补体分子基序分布概况,并就两种最常见的基序SCR与TSR进行了分析讨论。
About 30 percent of the 30 components of the human complement system contain some common structural sequence. It is now known that these motifs are SCR (CCP), TSR, EGF precursor, LDL-R, FIM, SP and the like. Among the complement molecules, some contain only one motif. For example, the RCA molecule only contains SCR, and the P molecule contains only TSRs; some contain a variety of motifs such as C6, C7, C8 and C9. Some kinds of motifs occupy a large proportion of complement molecules with few, such as H factor and C4bp, which are almost entirely composed of SCRs, most of which are composed of TSRs; some of them are only part of molecular structures such as C2, Bf, MCP, DAF, C9 and so on. The above motifs are located in the molecule, some at the amino terminus and some at the carboxy terminus. Some ends have. This paper presents an overview of the distribution of complement motifs and discusses the two most common motifs, SCR and TSR.