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目的探讨直肠放置米索前列醇联合利多卡因用于人工流产扩张宫颈镇痛的效果。方法 300例早孕妇女,随机分为3组,A组(利多卡因组)于宫颈3、9点处注射利多卡因各1 ml;B组(米索前列醇组)术前2 h直肠放置米索前列醇400μg;C组(米索前列醇联合利多卡因组),直肠放置米索前列醇400μg,2 h后宫颈3、9点处注射利多卡因各1 ml。观察三组宫颈扩张情况、镇痛效果、并发症、人工流产综合征发生率及出血量。结果 C组镇痛效果明显优于A、B组(P<0.01),且手术时间短。C组宫颈扩张程度优于A组(P<0.01),与B组相比差异无统计学意义(P>0.05)。B、C组无一例发生人工流产综合征,A组发生1例人工流产综合征。结论直肠放置米索前列醇400μg联合利多卡因用于人工流产可达到扩张宫颈、镇痛的良好效果,用药简单,安全,有效,可推广使用。
Objective To investigate the effect of misoprostol combined with lidocaine in the treatment of induced abortion cervical pain. Methods 300 early pregnancy women were randomly divided into 3 groups. Group A (lidocaine group) received 1 ml of lidocaine at 3 and 9 points respectively. Group B (misoprostol group) was placed rectally 2 hours before operation 400μg of misoprostol; Group C (misoprostol combined with lidocaine group), 400μg of misoprostol was placed in the rectum, and 1ml of lidocaine was injected at 3,9 point of the cervix 2 hours later. Three groups of cervical dilatation, analgesic effect, complications, incidence of induced abortion syndrome and bleeding volume were observed. Results The analgesic effect of group C was better than that of group A and B (P <0.01), and the operation time was short. The cervical dilation in group C was better than that in group A (P <0.01), but there was no significant difference between group C and group B (P> 0.05). No cases of abortion syndrome occurred in group B and C, and 1 case of induced abortion syndrome occurred in group A. Conclusion Rectal misoprostol 400μg combined with lidocaine for abortion can achieve the expansion of the cervix and analgesia good effect, medication is simple, safe and effective, and can be used widely.