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目的:探讨复发性念珠菌阴道炎的病因、临床治疗方法及效果。方法:选择我院2008年1月—2009年1月收治复发性念珠菌阴道炎患者60例,其中30例口服酮康唑治疗,400mg,1次/d,连服7d,设为对照组;30例服用氟康唑胶囊150mg,1次/d,连服7d,设为观察组,同时配偶需口服氟康唑150mg,1次即可。治疗1周、4周后比较两组患者的临床疗效、复发率及不良反应情况。结果:治疗4周后观察组的总有效率为96.7%(29/30),显著高于对照组83.3%(25/30),复发率显著优于对照组,P<0.05;两组在治疗1周后不良反应差异无统计学意义,P>0.05。结论:氟康唑胶囊治疗复发性念珠菌阴道炎远期疗效较好,可避免复发,副反应少,值得临床推广。
Objective: To investigate the etiology, clinical treatment and effect of recurrent Candida vaginitis. Methods: Sixty patients with recurrent Candida vaginitis were selected from January 2008 to January 2009 in our hospital. Among them, 30 cases were treated with ketoconazole, 400 mg once daily, and served for 7 consecutive days. 30 patients took fluconazole capsules 150mg, 1 time / d, and even served 7d, as the observation group, while spouses need oral fluconazole 150mg, 1 time can be. After 1 week and 4 weeks, the clinical efficacy, relapse rate and adverse reactions of the two groups were compared. Results: After 4 weeks of treatment, the total effective rate of the observation group was 96.7% (29/30), significantly higher than that of the control group (83.3%, 25/30), the recurrence rate was significantly better than the control group, P <0.05; There was no significant difference in adverse reactions after 1 week (P> 0.05). Conclusion: Fluconazole capsule treatment of recurrent Candida vaginitis better long-term efficacy, to avoid recurrence, fewer side effects, worthy of clinical promotion.