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用白介素6(IL-6)依赖细胞株7TD_1细胞,测定了21例原发性IgA肾病(IgAN)患者尿和血清IL-6活性水平,并分析了IL-6活性水平与IgAN临床及病理改变的联系.结果示IgAN尿及血清IL-6活性均增高(分别占46.7％及25％),尿IL-6活性增高与血清IL-6活性水平无平行关系.尿IL-6活性水平与IgAN严重蛋白尿的发生以及肾小球病变程度(节段肾小球硬化、新月体、系膜增生等)有关,亦与小管-间质病变的严重程度有关.因而尿IL-6测定,对IgAN的临床分析具有十分重要的意义.
Urinary and serum IL-6 levels were measured in 21 patients with primary IgA nephropathy (IgAN) using interleukin-6 (IL-6) -dependent cell line 7TD_1 and their clinical and pathological changes were analyzed The results showed that IgAN urinary and serum IL-6 activity were increased (46.7% and 25%, respectively), urinary IL-6 activity increased and serum IL-6 activity level was not paralleled with urinary IL-6 activity levels and IgAN Serious proteinuria and glomerular lesions (segmental glomerulosclerosis, crescent, mesangial proliferation, etc.), but also with the severity of tubulointerstitial disease, and thus urinary IL-6 determination of Clinical analysis of IgAN is of great importance.