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本文旨在探讨盆腔恶性肿瘤的介入性治疗问题。对45例患有盆腔恶性肿瘤的患者,采用Seldinger法,经双侧股动脉插管,先端选择性导入对侧髂内动脉;或一侧导入肠系膜下动脉,另侧导入髂内动脉,留置导管12小时,使用突击剂量持续灌注化疗药物。并经手术、B超、CT、内窥镜及指检等方法进行化疗前后的对比观察。结果:其中病灶消失持续1个月以上者9例、病灶缩小50％以上并持续超过一个月者23例、缩小不足50％且增大未达25％者9例、增大超过25％以上者4例,总有效率为71.1％。10例患者出现了脱发及皮肤色素沉着,1例患者出现下肢动脉栓塞,10例出现了不同程度的消化道反应等。结论:本法损伤小,操作简便安全,可多次重复术式:选择性强,药效持久均衡且毒副作用小;可提高手术切除率,也为不能手术的癌肿提供一种较理想的治疗手段。
This article aims to investigate the interventional treatment of pelvic malignancies. For 45 patients with pelvic malignancy, the Seldinger method was adopted. The bilateral femoral artery was cannulated and the tip was selectively introduced into the contralateral internal iliac artery; one side was introduced into the inferior mesenteric artery and the other into the internal iliac artery. For 12 hours, chemotherapeutic drugs were continuously infused using an assault dose. After surgery, B-ultrasound, CT, endoscopy and digital examinations were compared before and after chemotherapy. Results: Among them, 9 cases whose lesions disappeared for more than 1 month, 23 cases whose lesions were reduced by more than 50% and lasted for more than one month, 9 cases with less than 50% and less than 25%, and those with more than 25% increase. In 4 cases, the total effective rate was 71.1%. Hair loss and skin pigmentation occurred in 10 patients, arterial embolism in the lower extremities occurred in 1 patient, and different degrees of digestive tract reactions occurred in 10 patients. Conclusion: This method is small in damage, simple and safe to operate, and can be repeated multiple times: strong selectivity, long-lasting balance of efficacy and low side effects; it can increase the surgical resection rate, and it also provides an ideal for inoperable cancer. treatment approach.