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目的研究微生态制剂思连康辅助治疗溃疡性结肠炎的疗效及其可能的机制。方法将溃疡性结肠炎患者79例随机分成治疗组及对照组,治疗组40例,对照组39例。对照组采用常规治疗,治疗组在常规治疗的基础上加用双歧四联活菌制剂——思连康。比较2组治疗前及治疗2个月后患者的临床症状评分、结肠黏膜炎症表现、细胞因子IL-10、IL-18的变化。结果治疗2个月后2组临床症状评分、结肠黏膜炎症评分均较治疗前有明显改善(P<0.01),且治疗组临床症状、结肠黏膜炎症改善程度优于对照组(P<0.01),IL-10、IL-18的含量治疗前后有明显的变化,IL-10增加,IL-18降低。结论思连康可辅助治疗溃疡性结肠炎,其机制可能是通过调节细胞因子的变化,进一步影响结肠黏膜的免疫功能。
Objective To study the efficacy and probable mechanism of probiotics in the treatment of ulcerative colitis. Methods A total of 79 patients with ulcerative colitis were randomly divided into treatment group and control group, 40 cases in treatment group and 39 cases in control group. The control group with conventional treatment, the treatment group on the basis of conventional treatment plus bifidobacterium quadriceps preparation - Silian Kang. The scores of clinical symptoms, colonic mucosal inflammation, cytokines IL-10 and IL-18 in two groups before treatment and after 2 months of treatment were compared. Results After 2 months of treatment, the scores of clinical symptoms and colonic mucosal inflammation in both groups were significantly improved (P <0.01), and the improvement of clinical symptoms and colonic mucosal inflammation in the treatment group was better than that in the control group (P <0.01) IL-10, IL-18 content before and after treatment there are significant changes in IL-10 increased IL-18 decreased. Conclusions Silicone can aid in the treatment of ulcerative colitis. Its mechanism may be that it may further affect the immune function of colonic mucosa by regulating the changes of cytokines.