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生长抑素(SRIF)最初从下丘脑中分离得到,1973年产生了人工合成品,随着放射免疫的测定技术和免疫细胞化学技术的使用,很快发现SRIF在体内广泛合成,不仅下丘脑,而且脑的其它部分、胰岛、胃肠粘膜及外周神经等部分都有SRIF。1975年英国学者第一次发现SRIF不仅抑制体内众多的激素,而且还可抑制胃酸的释放,由于当时使用的SRIF剂量较大,结果观察到体内的生长素,胰岛素、胰岛血糖素等激素全部受到了抑制,我们后来仔细做了一个剂量反应试验,结果发现在很小的剂量0.06μg/kg、甚至再小至0.03μg/kg,SRIF就有显著的对胃泌素释放的抑制效应,在狗、SRIF剂量与胃泌素释放抑制效应呈几
Somatostatin (SRIF) was originally isolated from the hypothalamus and produced artificial products in 1973. With the application of radioimmunoassay and immunocytochemistry, SRIF was rapidly found to be widely synthesized in the body. Not only hypothalamus, And other parts of the brain, islets, gastrointestinal mucosa and peripheral nerve and other parts have SRIF. 1975 British scholars first discovered that SRIF not only inhibits many hormones in the body, but also inhibit gastric acid release, due to the larger doses of SRIF at the time, the results observed in the body of all auxin, insulin, Suppression, we later conducted a dose-response test carefully and found that SRIF had a significant inhibitory effect on gastrin release at very small doses of 0.06 μg / kg and even as little as 0.03 μg / kg, , SRIF dose and gastrin release inhibitory effect was a few