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目的 观察妊娠高血压综合征 (简称妊高征 )患者的血浆纤维蛋白原 (Fbg)、D 二聚体 (D Dimer)的变化 ,探讨其对妊高征血栓前状态 (PTS)的诊断意义。方法 采用单抗ELISA双抗体夹心法和全自动血凝仪检测正常非妊娠妇女 70例、正常晚期妊娠妇女 75例和 6 5例妊高征患者的Fbg、D Dimer等指标。 结果 与正常非孕组及正常晚期妊娠组比较 ,妊高征组Fbg、D Dimer水平均显著增高 ,并随病情加重而呈增高趋势。结论 正常妊娠妇女存在高凝状态 ,而妊高征患者存在明显血栓前状态。产前测定Fbg、D Dimer,对妊高征的防治和妊高征血栓前状态的诊断具有重要价值。
Objective To observe the changes of plasma fibrinogen (Fbg) and D-dimer (D-dimer) in patients with pregnancy induced hypertension (PIH), and to explore its diagnostic value in prethrombotic state of pregnancy-induced hypertension (PTS). Methods Fbg, D Dimer and other indexes of 70 non-pregnant women, 75 normal pregnant women and 65 pregnancy-induced hypertension syndromes were detected by monoclonal antibody ELISA double antibody sandwich method and automatic coagulation analyzer. Results Compared with normal non-pregnant group and normal late pregnancy group, the levels of Fbg and D Dimer in PIH group were significantly increased, and increased with the progression of the disease. Conclusion There is a hypercoagulable state in normal pregnant women, while patients with PIH have obvious prethrombotic state. Prenatal determination of Fbg, D Dimer, the prevention and treatment of pregnancy-induced hypertension and PIH diagnosis of pre-embolic status is of great value.