论文部分内容阅读
目的:分析2013-2014年湖南省湘潭市手足口病(HFMD)病原体型别及分布特征,为进一步完善HFMD的预防和治疗提供依据。方法:采用RT-PCR方法,对571例HFMD患儿进行肠道病毒通用型核酸(EV-RNA)、EV71及柯萨奇病毒A16(CA16)检测。结果:2013年除EV71及CA16外其他EV核酸阳性率75.30%,明显高于EV71的17.65%和CA16的7.05%(P<0.05),2014年EV71型核酸阳性率为50.68%,明显高于CA16的19.93%和其他EV的29.39%(P<0.05)。重症HFMD患儿EV71感染率明显高于轻症。结论:2013年湘潭地区HFMD患儿以除EV71及CA16外的其他EV病毒感染为主,2014年湘潭地区HFMD患儿以EV71感染为主。
Objective: To analyze the types and distribution of pathogen of HFMD from 2013 to 2014 in Xiangtan City, Hunan Province, and to provide basis for further improvement of HFMD prevention and treatment. Methods: 571 children with HFMD were tested for EV-RNA, EV71 and Coxsackie virus A16 (CA16) by RT-PCR. Results: The positive rate of other EV nucleic acids in EV71 and CA16 was 75.30% in 2013, which was significantly higher than that of EV71 17.65% and CA5 7.05% (P <0.05). The positive rate of EV71 was 50.68% in 2014, which was significantly higher than that of CA16 19.93% and other EV 29.39% (P <0.05). The infection rate of EV71 in children with severe HFMD was significantly higher than that of mild ones. Conclusion: In 2013, HFMD patients in Xiangtan were mainly infected with EVs other than EV71 and CA16. In 2014, EV71 infection was the main cause of HFMD in Xiangtan area.