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目的探讨Werner(WRN)基因与中国人群脑膜瘤发病风险的关联。方法对215例病理确诊的脑膜瘤病人和219例健康人,采用Snapshot方法对4个多态性位点(rs3024239、rs2725364、rs1800392、rs1801195)进行基因分型,比较脑膜瘤与健康人群之间WRN基因不同位点基因频率分布差异,并根据性别、年龄及病理亚型进行分层分析。结果 rs3024239多态性位点与内皮型脑膜瘤发病关联,rs3024239位点携带等位基因C的人群内皮型脑膜瘤的发病风险较低(P=0.015)。余3个位点多态性与脑膜瘤无明显相关性(均P>0.05);4个位点基因多态性与不同年龄与性别的脑膜瘤人群的发病风险无明显相关(均P>0.05)。结论中国人群中WRN基因多态性可能与脑膜瘤的发病风险具有相关性,rs3024239位点等位基因C能降低内皮型脑膜瘤的发病风险。
Objective To investigate the association between Werner (WRN) gene and the incidence of meningioma in Chinese population. Methods 215 patients with pathologically confirmed meningiomas and 219 healthy individuals were genotyped by Snapshot to compare the polymorphisms of rs3024239, rs2725364, rs1800392, rs1801195, and WRN Genes at different sites of gene frequency distribution differences, and according to gender, age and pathological subtype stratified analysis. Results The rs3024239 polymorphism was associated with the incidence of endothelial meningiomas, and the risk of developing endothelial meningiomas was lower in those with allele C at rs3024239 (P = 0.015). No significant correlation was found between the three polymorphisms and meningiomas (all P> 0.05). There was no significant correlation between the polymorphisms at 4 loci and the incidence of meningioma in different age and gender groups (all P> 0.05 ). Conclusion The polymorphism of WRN gene in Chinese population may be related to the risk of meningioma. The allele C at rs3024239 may reduce the incidence of endothelial meningioma.