天津市正常人尿总羟脯氨酸,脯氨酸、羟赖氨酸和赖氨酸分析及某些生理因素对其排泄的影响

• 作 者: 齐建成 徐桂珍 耿兆波 尹潍
• 机 构: 天津医学院附属医院内分泌科,天津医学院附属医院内分泌科,天津医学院附属医院内分泌科,天津医学院附属医院内分泌科,
• 出 处: 天津医药
• 发表日期: 1988年04期
• 关键词: 羟赖氨酸 正常人尿 脯氨酸 高效液相色谱仪 胶原蛋白 转换率 差异无显著性 胶原 胶原纤维 半乳糖

采用高效液相色谱仪分析了112例天津市不同年龄组正常人尿的羟脯氨酸、脯氨酸、羟赖氨酸和赖氨酸含量。结果表明:1.羟脯氨酸和羟赖氨酸的排泄与年龄有关,9～15岁为最高峰,26～40岁趋恒定。2.胶原饮食对尿羟脯氨酸、脯氨酸、羟赖氨酸及赖氨酸的排泄有影响;普通饮食和素食对其排泄影响不大。3.男女之间差异无显著性。4.测定尿中的这些胶原蛋白的氨基酸,特别是羟脯氨酸和羟赖氨酸能反映体内胶原的转换率。

The contents of hydroxyproline, proline, hydroxylysine and lysine in urine of 112 normal subjects of different age groups in Tianjin were analyzed by high performance liquid chromatography. The results showed that: 1.Excretion of hydroxyproline and hydroxylysine was related to age, with the highest peak at 9 to 15 years old and the constant at 26 to 40 years old. Collagen diet on urinary hydroxyproline, proline, hydroxylysine and lysine excretion have an impact; ordinary diet and vegetarian excretion little effect. The difference between men and women was not significant. Determination of amino acids in the urine of these collagen, especially hydroxyproline and hydroxylysine can reflect the conversion rate of collagen in vivo.