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目的探讨血尿酸(BUA)及血清胱抑素C(CysC)水平与冠状动脉病变的关系。方法选取2014年1月—2016年4月因胸痛、心悸入住常州市金坛区人民医院并行冠状动脉造影检查的患者352例,根据冠状动脉造影检查结果分为冠状动脉病变组241例和非冠状动脉病变组111例;根据冠状动脉狭窄程度分为无狭窄组111例、轻度狭窄组95例、中度狭窄组61例和重度狭窄组85例;根据冠状动脉病变支数分为无病变组111例、单支病变组51例、双支病变组84例和多支病变组106例。采用乳胶颗粒免疫比浊法检测BUA及血清CysC水平,比较不同冠状动脉病变情况患者BUA及血清CysC水平。结果冠状动脉病变组患者BUA及血清CysC水平高于非冠状动脉病变组(P<0.05)。重度狭窄组患者BUA及血清CysC水平高于中度狭窄组,中度狭窄组患者BUA及血清CysC水平高于轻度狭窄组,轻度狭窄组患者BUA及血清CysC水平高于无狭窄组(P<0.05)。多支病变组患者BUA及血清CysC水平高于双支病变组,双支病变组患者BUA及血清CysC水平高于单支病变组,单支病变组患者BUA及血清CysC水平高于无病变组(P<0.05)。结论 BUA及血清CysC水平可预测冠状动脉病变的发生,且BUA及血清CysC水平升高的冠状动脉病变患者冠状动脉狭窄程度较重。
Objective To investigate the relationship between serum creatinine (BUA), serum cystatin C (CysC) and coronary artery disease. Methods From January 2014 to April 2016, 352 patients with chest pain and palpitation admitted to Changzhou Jintan District People’s Hospital undergoing coronary angiography were divided into two groups according to coronary angiography: 241 patients with coronary artery disease and non-coronary According to the degree of coronary artery stenosis, there were 111 cases without stenosis group, 95 cases with mild stenosis group, 61 cases with moderate stenosis group and 85 cases with severe stenosis group. According to the degree of coronary artery lesion, there were 111 cases without lesions 111 cases, 51 cases of single-vessel disease group, 84 cases of double-vessel disease group and 106 cases of multi-vessel disease group. The levels of BUA and serum CysC were measured by latex immunoturbidimetry and the levels of BUA and serum CysC in patients with different coronary lesions were compared. Results The serum levels of BUA and CysC in patients with coronary artery disease were significantly higher than those in patients without coronary artery disease (P <0.05). The levels of BUA and CysC in patients with severe stenosis were higher than those in patients with moderate stenosis. The levels of BUA and CysC in patients with moderate stenosis were higher than those in patients with mild stenosis. The levels of BUA and CysC in patients with mild stenosis were higher than those without stenosis <0.05). The levels of BUA and serum CysC in patients with multi-vessel disease were higher than those in patients with double-vessel disease. The levels of BUA and serum CysC in patients with double vessel disease were higher than those in patients with single vessel disease. The levels of BUA and serum CysC in patients with single vessel disease were higher than those without disease P <0.05). Conclusions BUA and serum CysC level can predict the occurrence of coronary artery disease, and coronary artery stenosis is more severe in patients with coronary artery disease with elevated levels of BUA and serum CysC.