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血脑屏障是分隔外周血和大脑的屏障,选择性地允许或阻止物质在两者间的通透。近年来陆续有研究指出,血脑屏障存在大量转运体参与重要生理物质选择性进入大脑,并且将代谢产物转运入血以维持脑内环境稳定。血脑屏障功能失调与很多脑疾病密切相关。基因组学与蛋白质组学等研究方法的介入可高通量、大规模地研究血脑屏障中的转运体,极大地加快了人们对血脑屏障在疾病发生发展中的作用以及临床治疗研究中的认识。
The blood-brain barrier is a barrier that separates the peripheral blood from the brain, selectively allowing or preventing the passage of material between the two. In recent years, studies have pointed out that there are a large number of blood-brain barrier transporters involved in the selective entry of important physiological substances into the brain, and metabolites into the blood in order to maintain a stable brain environment. Blood-brain barrier dysfunction is closely related to many brain diseases. Involvement of genomics and proteomics in high-throughput, large-scale studies of transporters in the blood-brain barrier has greatly accelerated the role of the blood-brain barrier in disease progression and in clinical trials understanding.