论文部分内容阅读
目的从镇痛效果、生活质量、药物不良反应等方面综合评价芬太尼透皮贴剂对中重度癌痛的治疗效果。方法采用标准病例报告表,结合BPI简明疼痛评估表及NRS数字评分法等方法,对39例首次接受芬太尼透皮贴剂治疗(初始剂量25μg.h-1)的中重度癌痛的患者进行为期5周的用药观察,详细记录病程发展过程并进行汇总分析。结果本实验中39例入组患者治疗有效率97.4%(38/39),平均癌痛缓减幅度达60.3%,患者生活质量改善显著,主要不良反应为便秘、头晕、恶心、嗜睡、皮肤瘙痒等,多数可耐受且治疗后期趋于缓解。结论芬太尼透皮贴剂对中重度癌痛疗效显著,药物不良反应较少,较明显改善患者生活质量,可作为中重度癌痛治疗的推荐药物之一。
Objective To evaluate the therapeutic effect of fentanyl transdermal patch on moderate to severe cancer pain in terms of analgesic effect, quality of life and adverse drug reactions. Methods Thirty-nine patients with moderate-to-severe cancer pain who were initially treated with transdermal fentanyl (initial dose of 25 μg · h -1) were treated with standard case report form, BPI brief assessment of pain scale and NRS digital scoring method. For 5 weeks of medication observation, detailed record of the course of disease development and summary analysis. Results In the experiment, the effective rate of treatment was 97.4% (38/39) in 39 patients and the average reduction rate of cancer pain was 60.3%. The quality of life of patients improved significantly. The main adverse reactions were constipation, dizziness, nausea, lethargy and pruritus Mostly tolerated and later treated tend to ease. Conclusions Fentanyl transdermal patch has significant effect on moderate and severe cancer pain, less adverse drug reactions, and obviously improves the quality of life of patients. It can be used as one of the recommended drugs for the treatment of moderate-severe cancer pain.