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目的 :观察桃红四物汤加味方治疗小儿难治性肾病的治疗作用。方法 :将 95例患儿随机分为桃红四物汤组 ( 60例 ,用桃红四物汤加味方治疗 )与肝素组 ( 35例 ,用肝素治疗 ) ,观察治疗前后血栓素B2(TXB2 )、6 酮 前列环素F1α( 6 keto PGF1α)水平与临床疗效。结果 :桃红四物汤组总有效率为 81 7% ,疗效与肝素组 ( 80 0 % )近似 (P >0 0 5) ;治疗前两组患儿TXB2 、TXB2 / 6 keto PGF1α均高于健康对照组 (P <0 0 1) ,治疗后均有明显改变 ,与治疗前比较 ,差异有显著性 (P <0 0 1) ,桃红四物汤组与肝素组治疗后比较差异无显著性 (P >0 0 5)。结论 :桃红四物汤加味方治疗小儿难治性肾病有良好作用 ,并有改善肾病患儿血栓素、前列环素代谢失衡作用
Objective: To observe the therapeutic effect of Taohong Siwu Decoction in treating infantile refractory nephropathy. Methods: Ninety-five children were randomly divided into Taohong Si Wu Decoction group (60 cases, treated with Taohong Siwu Decoction) and heparin group (35 cases treated with heparin). The levels of TXB2, Keto prostacyclin F1α (6 keto PGF1α) levels and clinical efficacy. Results: The total effective rate in Taohong Siwu Decoction group was 81.7%, and the curative effect was similar to that in heparin group (80%) (P> 0.05). The levels of TXB2 and TXB2 / 6 keto PGF1α in the two groups before treatment were significantly higher than those in healthy group (P <0.01), there was a significant difference after treatment (P <0.01), and there was no significant difference between Taohongsiwutang group and heparin group P> 0 0 5). Conclusion: Taohong Siwu Tang Jiawei recipe can treat refractory nephropathy in children and has the effect of improving the unbalance of thromboxane and prostacyclin metabolism in children with nephropathy