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男患,16岁。因确诊急性单核细胞白血病两年,化疗后完全缓解一年余,于1987年9月17日第八次入院使用HOAP维持治疗,9月26日9时在局麻下行鞘内注射治疗,测脑压正常,即误将一支100mg MTX作为5mg量全部注入蛛网膜下腔,约10分钟后患者开始感头痛胸闷不适,随之出现频繁喷射状呕吐,系胃内容物。复核发现用药过量。立即采取反复放脑脊液以减低脑脊液中MTX浓度的措
Male suffering, 16 years old. Due to the diagnosis of acute monocytic leukemia for two years, completely relieved after chemotherapy more than one year, on the eighth hospital admission on September 17, 1987 HOAP maintenance treatment at 9:00 on September 26 in the local anesthesia intrathecal injection therapy Normal brain pressure, which mistakenly put a 100mg MTX as 5mg dose into the subarachnoid space, about 10 minutes after the patient began to feel headache chest discomfort, followed by frequent jet-like vomiting, Department of stomach contents. Review found overdose. Immediately take repeatedly put cerebrospinal fluid to reduce the concentration of MTX in CSF