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目的观察地特胰岛素与二甲双胍联合治疗初发2型糖尿病的临床效果。方法选取医院收治的患有初发2型糖尿病的患者100例,随机分为对照组和观察组,每组50例。对照组给予地特胰岛素进行治疗,观察组给予地特胰岛素与二甲双胍联合治疗,观察比较2组患者在治疗前后血糖变化,包括空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(Hb A1c),观察比较2组治疗效果。结果治疗后,2组FBG、2 h PBG、Hb A1c水平均下降,观察组FBG、2 h PBG、Hb A1c水平低于对照组(P均<0.01);观察组总有效率为94.00%,高于对照组的80.00%(P<0.05)。结论针对治疗初发2型糖尿病患者采用地特胰岛素与二甲双胍进行联合治疗,可有效提高其治疗效果,值得临床上广泛应用。
Objective To observe the clinical efficacy of detemir and metformin in the treatment of newly diagnosed type 2 diabetes mellitus. Methods Totally 100 patients with newly diagnosed type 2 diabetes admitted to hospital were randomly divided into control group and observation group, with 50 cases in each group. The control group was given insulin detemir for treatment. The observation group was given detemir insulin combined with metformin. The changes of blood glucose, including fasting blood glucose (FBG), 2 h postprandial glucose (2 h PBG), glycosylated Hemoglobin (Hb A1c) was observed and compared between the two groups. Results After treatment, the levels of FBG, 2 h PBG and Hb A1c in both groups decreased, while the levels of FBG, 2 h PBG and Hb A1c in the observation group were lower than those in the control group (all P <0.01). The total effective rate in the observation group was 94.00% 80.00% of the control group (P <0.05). Conclusions The combination of detemir and metformin for the treatment of newly diagnosed type 2 diabetes mellitus patients can effectively improve their therapeutic effect and is worthy of clinical application.