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5羟色胺属于造血型放射损伤的防护剂之一,它能明显提高受照射动物的CFU-S的活存数。本文试图说明,5羟色胺对其它阶段的细胞是否也有防护作用?怎样表现?是仅对照前未损伤的细胞有效,还是对损伤的细胞也有效? X线照前15分钟或照后立即给每只(CBA×C57B1)F_1小鼠皮下注射5羟色胺0.5或2.0mg。照后3～20天检查股骨骨髓有核细胞数和脾重,计算第8天内
Serotonin is one of the protective agents for hematopoietic radiation injury. It can significantly increase the survival of CFU-S in irradiated animals. This article attempts to show whether serotonin also has protective effects on other stages of cells, how it behaves, whether it is effective only for cells that have not been damaged before the control, or whether it is also effective for injured cells. Each line is given 15 minutes before X-ray irradiation or immediately afterwards. (CBAxC57Bl) Fl mice were injected subcutaneously with serotonin 0.5 or 2.0 mg. After 3 to 20 days, the bone marrow nucleated cell count and spleen weight were checked and calculated within the 8th day.