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目的探究乙型肝炎病毒及丙型肝炎病毒重叠感染患者生化免疫指标变化与临床意义。方法抽取2014年5月—2016年7月镇平县中医院134例肝炎患者,根据病理检查结果分为乙型肝炎组(n=43)、丙型肝炎组(n=46)、重叠感染组(n=45)。抽取所有患者空腹肘静脉血检测,采用SPSS19.0对数据进行分析,对比各组INF-γ诱导蛋白10(IP-10)、γ-干扰素(IFN-γ)及肝功能相关指标[总胆红素(TBil)、谷草转氨酶(AST)、谷丙转氨酶(ALT)]表达水平,并以Child-Pugh评分量表对患者肝脏储备功能进行评分。结果重叠感染组TBil(21.54±8.04)umol/L、AST(70.25±10.35)U/L、ALT(75.72±13.03)U/L表达水平及Child-Pugh评分(10.64±1.65)分均明显高于丙型肝炎组,乙型肝炎组TBil、AST、ALT表达水平明显高于重叠感染组,差异有统计学意义(P<0.05);重叠感染组INF-γ水平为(15.52±4.62)ng/ml,IP-10水平为(621.83±57.53)ng/ml,均明显高于乙型肝炎组及丙型肝炎组,差异有统计学意义(P<0.05);乙型肝炎组及丙型肝炎组间INF-γ及IP-10水平对比差异无统计学意义(P>0.05)。结论乙型肝炎病毒及丙型肝炎病毒重叠感染不会对患者肝功能造成影响,但更易引发肝组织炎症反应,损害肝脏储备功能。
Objective To explore the changes and clinical significance of biochemical and immunological indexes in hepatitis B virus and hepatitis C virus overlapping patients. Methods Totally 134 patients with hepatitis from Zhenping Hospital of Traditional Chinese Medicine from May 2014 to July 2016 were divided into hepatitis B group (n = 43), hepatitis C group (n = 46), overlapping infection group (n = 45). The fasting cubital vein blood was collected from all patients. The data were analyzed by SPSS19.0. The levels of INF-γ-induced protein 10 (IFN-γ), interferon-γ (IFN-γ) TBil, AST and ALT were measured. Liver function of patients was scored by Child-Pugh score scale. Results The levels of TBil (21.54 ± 8.04) umol / L, AST (70.25 ± 10.35) U / L and ALT (75.72 ± 13.03) U / L and Child-Pugh score (10.64 ± 1.65) The levels of TBil, AST and ALT in hepatitis C and hepatitis B group were significantly higher than those in overlap infection group (P <0.05). The levels of INF-γ in overlap group were (15.52 ± 4.62) ng / ml , And the level of IP-10 was (621.83 ± 57.53) ng / ml, both of which were significantly higher than those of hepatitis B and hepatitis C. The difference was statistically significant (P <0.05); between hepatitis B and hepatitis C There was no significant difference in INF-γ and IP-10 levels (P> 0.05). Conclusion Hepatitis B virus and Hepatitis C virus overlap infection will not affect the liver function of patients, but more likely to cause liver inflammation and damage the liver reserve function.